Trovafloxacin, a broad-spectrum fluoroquinolone, was found to have unexpected side effects of severe hepatotoxicity, which was not detected by preclinical testing
The affinity of the ubiquitin receptor for the proteasome pathway is stronger, but as the substrate aggregates, the autophagy receptor increases its affinity for ubiquitin
In our clinical approach, we often strategically combine both peptides
Latiano A, Palmieri O, Corritore G, Valvano MR, Bossa F, Cucchiara S et al
doi: 10.3389/fendo.2025.1572997 Received 08 February 2025 Accepted 25 June 2025 Published 10 July 2025 Volume 16 - 2025 Edited by Terry Francis Davies, Icahn School of Medicine at Mount Sinai, United States Reviewed by Morteza Gholami, Golestan University, Iran Lucia Acampora, University of Naples Federico II, Italy Updates Copyright 2025 Cui, Wang, Li, Liu, Wang and Zhao
Zhang M, Qin X, Zhao Z, Du Q, Li Q, Jiang Y, et al